How does paracetamol work?
Paracetamol, also known as acetaminophen, is a popular pain reliever and fever reducer. It works by reducing the body's production of prostaglandins, substances that cause pain and fever. Paracetamol acts centrally in the nervous system and increases the pain threshold, thus reducing pain sensation. It is commonly used for headaches, muscle pain, arthritis, and fever.
Combining alcohol and paracetamol
With normal alcohol consumption, it is safe to combine it with acetaminophen. However, the combination of acetaminophen and excessive alcohol can be harmful to the liver. Alcohol metabolism leads to the production of acetaldehyde, a toxic substance that can damage the liver. Acetaminophen is also metabolized in the liver, and in high doses, it can produce a toxic substance, NAPQI, which can damage liver cells without sufficient glutathione. Simultaneous alcohol consumption can reduce the availability of glutathione, increasing the risk of liver damage.
Side effects of alcohol and paracetamol
Combining paracetamol with alcohol can lead to increased liver strain and, in severe cases, acute liver failure. Symptoms of a possible interaction include nausea, vomiting, sweating, pallor, and, in severe cases, jaundice. Long-term use of both substances increases the risk of chronic liver disease.
What dosage of paracetamol should I use?
The recommended maximum daily dose of acetaminophen for a healthy adult is 3,000 to 4,000 milligrams, divided into doses. However, when consuming alcohol simultaneously, it is recommended to reduce the dose to minimize the risk of liver damage. Individuals who regularly consume large amounts of alcohol may need to avoid acetaminophen or use a lower maximum dose, such as 2,000 milligrams per day.
Do you get drunk faster?
There is no direct evidence that taking acetaminophen makes people get drunk faster. The perception of getting drunk faster may have more to do with the general health of the liver and its efficiency in processing alcohol. However, combining alcohol with acetaminophen can place a greater burden on the liver, potentially slowing down the breakdown of alcohol and indirectly prolonging the feeling of being drunk.
