What is Resveratrol and where does it come from?
Resveratrol is an organic compound produced by plants as a natural defense against external stressors, such as UV radiation or fungi. It belongs to the stilbenes, a subcategory of polyphenols. Although red wine is often cited as a source, its concentration is relatively low.
For high-quality supplementation, extracts from Japanese knotweed ( Polygonum cuspidatum ) are often used. This plant naturally contains very high concentrations of the active ingredient, which allows for efficient and pure extraction.
The role of sirtuins
In biology, resveratrol is known for its interaction with specific proteins, the sirtuins (particularly SIRT1). These proteins play a role in various cellular processes related to metabolism and maintaining a healthy cell environment. By supporting these processes, resveratrol contributes to the body's natural ability to function optimally.
Trans-Resveratrol vs. Resveratrol: A Key Difference
When you delve into resveratrol, you'll immediately encounter the term "trans-resveratrol." This isn't a marketing term, but rather a designation for its molecular structure. Resveratrol occurs naturally in two forms (isomers):
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Trans-resveratrol: The biologically active form. This specific molecular structure is stable and is recognized and utilized by the body.
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Cis-resveratrol: A less stable form that often forms when trans-resveratrol is exposed to light or heat. This form is hardly absorbed biologically.
For effective results, it's essential to choose a supplement standardized to trans-resveratrol. This guarantees that the active molecules are actually present and effective.
The challenge of bioavailability
One of the most important considerations with resveratrol is its bioavailability. Although the substance is rapidly absorbed by the intestines after ingestion, it undergoes extensive metabolism in the liver (the "first-pass effect"). As a result, the free concentration of resveratrol in the systemic circulation often remains limited.
Synergy with other nutrients
Scientific insights show that the absorption of resveratrol can be promoted by combining it with specific other plant substances:
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Quercetin: This polyphenol can influence the conversion of resveratrol in the intestines and liver, which means the active substance remains available in the body for longer.
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Curcumin: The combination with curcumin is often recommended because of its complementary effect on cellular processes.
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Piperine (Black Pepper Extract): This extract is known to support the absorption of various nutrients through the intestinal wall.
Times of use and dosage
For optimal support, not only the quality but also the time of intake is important.
When to take?
Resveratrol is a fat-soluble compound. This means that taking it with a meal containing healthy fats can significantly improve its absorption. Many experts recommend taking it in the morning to align with the natural rhythm of metabolism and sirtuin activity.
Dosage
Within a conscious lifestyle, doses between 250 mg and 500 mg of trans-resveratrol per day are often used. These amounts provide solid support without disrupting the body's natural balance.
Quality and safety
Trans-resveratrol is generally very well tolerated. At very high doses (above 1,000 mg per day), mild digestive symptoms may occur. Therefore, it is advisable to follow the recommended daily amount.
At Vaud, clinical substantiation is paramount. We select only high-purity trans-resveratrol, free from unnecessary fillers, to provide a quality standard worthy of a premium health regimen.
Summary
Resveratrol is a powerful tool for those striving for a healthy lifestyle. By choosing the trans-isomer and combining it with a high-fat meal or synergistic substances like quercetin, you support your body in a scientifically proven way.
Frequently Asked Questions (FAQ)
Is red wine a good source of resveratrol? While red wine does contain resveratrol, the amounts are minimal. To achieve an effective dose, one would have to consume unhealthy amounts of wine. Supplementation offers a concentrated and responsible alternative.
What is the benefit of Japanese knotweed? Japanese knotweed is one of the richest natural sources of trans-resveratrol. Using this source guarantees a high concentration of the active ingredient in a stable form.
Can I combine resveratrol with other supplements? Yes, in professional settings, resveratrol is often combined with NMN or quercetin. These substances enhance each other's role in supporting cellular vitality.
Is resveratrol safe for long-term use? Research on long-term use in doses up to 500 mg per day shows a safe profile in healthy adults. Always consult a healthcare professional before using any medication.
